硫化物可能会冒着老年人皮肤癌的风险

根据4月12日在线公布的一项研究CMAJ.,加拿大医学协会杂志。

Aaron M. Drucker, M.D., from the University of Toronto, and colleagues conducted a population-based inception cohort study using linked administrative health data from Ontario for 1998 to 2017. Adults aged 66 years and older with a first prescription for an antihypertensive medication were matched by age and sex to two unexposed adults prescribed a nonantihypertensive medication within 30 days of the index date to examine associations with keratinocyte carcinoma and melanoma. The cohorts included 302,634 adults prescribed an antihypertensive medication and 605,268 unexposed adults.

研究人员发现,增加噻嗪类暴露的甲状腺细胞癌癌,先进的角质形成细胞癌和黑色素瘤(调节的危险比每一个定义的年剂量单位单位,1.08 [1.03至1.14],1.07 [0.93]到1.23],分别为1.34 [1.01至1.78]。没有发现其他抗高血压类和角质形成细胞癌或黑素瘤之间的关联的一致证据。

“我们发现一致的剂量依赖性增加与噻嗪类化合物,但没有与其他抗高血压阶级相关的皮肤癌症风险增加,”作者写道。“临床医生可以考虑噻嗪类利尿剂的替代品,以治疗皮肤癌高风险患者的高血压。”

若干作者披露了制药行业的财务关系。

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